Three major Northern Virginia interstates (I-95, I-66 and I-395) and two Suburban Maryland highways (I-270 and Route 50) connect the suburbs to downtown Washington, DC.

These highways are designed to accommodate significant high occupancy vehicle (HOV) travel, which encourages car and van pooling, thereby reducing highway congestion and emissions.

Regional interstates connecting the region to major cities across the country include I-95, I-70 and I-66.